Outcome at 1 year of neonatal encephalopathy in Kathmandu, Nepal

• DOI: 10.1111/j.1469-8749.1999.tb00524.x
• Publication Date: 2010-07-16T14:14:41Z
• Authors: Matthew Ellis; Nilu Manandhar; Prakash S Shrestha; Laxman Shrestha; Dharma S Manandhar; Anthony M De L Co...
• Keywords: Neonatal Encephalopathy

To determine the outcome at 1 year of neonatal encephalopathy (NE) and to estimate possible contribution birth asphyxia childhood disability in a low‐income South Asian country, prospective cohort study was undertaken principal maternity hospital Kathmandu, where over 50% local women give birth. From total population 21 609 live births, 131 term infants with NE (after exclusion cases associated sepsis, congenital malformations, or primary hypoglycaemia) 208 control were recruited. Of these, 102 (78%) 106 (51%) followed‐up age. Outcome measures death neurodevelopmental impairment, graded as major, minor none. NE, 83 moderate severe according conventional definition. By age, 45 (44%) had died, 18 (18%) impairments, two (2%) impairments; four (4%) subjects died impairments. Most deaths occurred early period; carried no excess risk beyond period. children major 14 spastic tetraplegic cerebral palsy eight multiple Compared group relative by 5 (95% CI 1.4 15) for mild 8 3 23) moderate, 26 10 67) severe. Twenty‐seven 38 (71%) either survived impairment. An upper prevalence neuroimpairment attributable is per 1000 births this population.