Differential engagement of anterior cingulate cortex subdivisions for cognitive and emotional function

• DOI: 10.1111/j.1469-8986.2007.00515.x
• Publication Date: 2007-04-24T17:22:29Z
• Authors: Aprajita Mohanty; Anna S. Engels; John D. Herrington; Wendy Heller; Moon‐Ho Ringo Ho; Marie T. Banich; Andrew G. Webb; Stacie L. Warren; Gregory A. Miller
• Keywords: Cingulate cortex

Abstract Functional differentiation of dorsal (dACC) and rostral (rACC) anterior cingulate cortex for cognitive emotional function has received considerable indirect support. Using fMRI, parallel tasks, within‐subject analysis, the present study directly tested proposed specialization ACC subdivisions. A Task × Region interaction confirmed more dACC activation during color‐word distractors rACC emotion‐word distractors. Activity in subdivisions differentially predicted behavioral performance. Connectivity with prefrontal limbic regions also supported distinct roles. Findings provide direct evidence differential engagement processing functional connectivity implementation control emotion regulation. Results point to an anatomical continuum rather than segregated operations.