Effects of hypoglycaemia on fetal heart activity and umbilical artery Doppler velocity waveforms in pregnant women with insulin‐dependent diabetes mellitus

• DOI: 10.1111/j.1471-0528.1996.tb09766.x
• Publication Date: 2005-08-19T09:49:07Z
• Authors: A. O. Björklund; U. K. C. Adamson; N. H. H. Almström; E. A. Enocksson; G. M. Gennser; P.‐E. S. Lins; L. M. R. Westgren
• Keywords: Umbilical artery

Objective To study the effect of induced hypoglycaemia on fetal wellbeing as indicated by heart rate and umbilical artery flow velocity waveforms. Design A prospective experimental investigation. Setting High risk pregnancy unit diabetes research at Karolinska Institutet, Danderyd Hospital, a university affiliated hospital. Participants Ten women with insulin‐dependent mellitus in third trimester pregnancy. Interventions The rate, blood waveforms maternal catecholamine levels were investigated during 150–minute hyperinsulinaemic hypoglycaemic clamp induction maintenance an arterial glucose level about 2.2 mmol/l. Main outcome measures 1. Fetal: changes pattern pulsatility index 2. Maternal: plasma adrenaline noradrenaline. Results Maternal was associated increase frequency amplitude accelerations, slight decrease rise levels. Conclusions We speculate that increased number accelerations reflects sympathico‐adrenal activity clamp. No potentially harmful effects fetus observed or Doppler waveform analysis hypoglycaemia.