THE INFLUENCE OF EXCESS METHIONINE ON THE FREE AMINO ACIDS OF BRAIN AND LIVER OF THE WEANLING RAT*

• DOI: 10.1111/j.1471-4159.1969.tb06458.x
• Publication Date: 2006-10-05T02:14:54Z
• Authors: R. G. Daniel; H. A. Waisman
• Keywords: Alanine; Amino acid synthesis; Aspartic acid; Weanling

Abstract— —High circulating levels of l ‐methionine produced by inclusion in the diet or parenteral injection amino acid caused alterations free pattern liver and brain tissues. Acute effects following were more pronounced than those long term feeding where adaptation played a role. The net effect was to increase total acids while decreasing brain. Individually, hepatic aspartic acid, threonine, serine, glutamine, glutamic glycine, alanine depressed taurine, cystathionine, methionine, lysine, ornithine markedly elevated. Brain alanine, γ‐aminobutyric increased glutamine observed. A generalized aminoaciduria occurred shortly after excessive methionine intake. Disruption pools two kinds. first depended on continued presence excess ‐methionine, second did not.