PLASMA CHOLINE: ITS TURNOVER AND EXCHANGE WITH BRAIN CHOLINE1

• DOI: 10.1111/j.1471-4159.1975.tb03856.x
• Publication Date: 2006-10-05T05:36:54Z
• Authors: J. J. Freeman; R. L. Choi; D. J. Jenden
• Keywords: Choline; Venous blood; Blood plasma; Compartment (ship); Turnover; Plasma levels

Abstract —The kinetics of plasma choline (Ch) and the uptake Ch into brain were studied by means intravenous infusion [ 2 H 4 ]Ch at various rates anaesthetized conscious rats. levels in both arterial venous steady state linearly related to rate; however, unlabelled independent rate. higher than plasma, while plasma. It was concluded that is being generated released effluent. The supply not decreased if level increased. clearance turnover compartment its initial distribution are 75 ml kg ‐1 min 716 nmol , respectively. saturated even very high Ch.