Examination of the Role of Central Cholinergic Mechanisms in the Therapeutic Effects of HI‐6 in Organophosphate Poisoning

• DOI: 10.1111/j.1471-4159.1983.tb13573.x
• Publication Date: 2006-12-16T02:20:58Z
• Authors: P. M. Lundy; T.‐M. Shih
• Keywords: Organophosphate poisoning; Intraperitoneal injection; Antidote; Cholinesterase

In atropine-pretreated rats, HI-6 (125 mg/kg i.p.) raised the LD50 of Soman (subcutaneous) 5.7 times. Addition (25 micrograms i.c.v.) failed to enhance this protection further. (intraperitoneal) also protected animals from intracerebroventricular Soman. HI-6, administered intracerebroventricularly either alone or in combination with intraperitoneal increase protection, nor did it reactivate Soman-inhibited acetylcholinesterase (AChE) several brain areas. 62.5 rats Sarin lethality, but only higher dose significantly altered AChE activity. Furthermore, block Soman-induced acetylcholine (ACh) choline (Ch) levels any areas examined. These data indicate that is a very beneficial therapy against Soman, no definitive central anticholinergic activity compound could be found explain its protective effects. It possible acts by noncholinergic mechanisms, produces effects outside CNS. does not appear indicative oxime. ACh Ch study were good parameters predict outcome poisoning.