Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring

• DOI: 10.1111/j.1471-4159.2006.03679.x
• Publication Date: 2006-02-08T11:58:13Z
• Authors: Joachim Kremersko...; Stefan Kindler; Indra Finger; Stefan Veltel; Angelika Barnekow
• Keywords: Postsynaptic density

Abstract Synaptic plasticity and memory formation involve remodeling of the postsynaptic cytoskeleton, a process that is in part based on both local translation dendritic mRNAs synaptic recruitment newly synthesized proteins. The component Dendrin encoded by dendritically localized mRNA thought to modulate structure cytoskeleton. However, molecular mechanisms control extrasomatic transport protein are unknown. data presented here reveal interacts with cytoskeletal components α‐actinin Maguk inverted orientation (MAGI) or scaffolding molecule (S‐SCAM). latter retains cytoplasm mammalian cells prevents its nuclear import. Furthermore neurons, clustering requires targeting messenger RNA (mRNA), mediated sequence motif within 3′ untranslated region. In summary our finding suggest appears critically depend synthesis association MAGI/S‐SCAM. Its localization capacity further points function retrograde signaling from synapse nucleus.