Tumor necrosis factor‐α activates signal transduction in hypothalamus and modulates the expression of pro‐inflammatory proteins and orexigenic/anorexigenic neurotransmitters

• DOI: 10.1111/j.1471-4159.2006.03857.x
• Publication Date: 2006-04-21T20:34:56Z
• Authors: Maria E. Amaral; Raquel Barbuio; Marciane Milanski; Talita Romanatto; Helena C. Barbosa; Wilson Nadruz; Manoel B. Bertolo; Antonio C. Boschero; Mario J. A. Saad; Kleber G. Franchini; Licio A. Velloso
• Keywords: Orexigenic; Energy homeostasis

Tumor necrosis factor-alpha (TNF-alpha) is known to participate in the wastage syndrome that accompanies cancer and severe infectious diseases. More recently, a role for TNF-alpha pathogenesis of type 2 diabetes mellitus obesity has been shown. Much regulatory action exerted by upon control energy stores depends on its hypothalamus. In this study, we show activates canonical pro-inflammatory signal transduction pathways hypothalamus rats. These signaling events lead transcriptional activation an early responsive gene induction expression cytokines cytokine protein such as interleukin-1beta, interleukin-6, interleukin-10 suppressor signalling-3, respectively. addition, induces neurotransmitters involved feeding thermogenesis. Thus, may act directly inducing response modulation homeostasis.