OCCURRENCE OF PROSTAGLANDIN E2 IN THE HUMAN STOMACH, AND A STUDY OF ITS EFFECTS ON HUMAN ISOLATED GASTRIC MUSCLE

• DOI: 10.1111/j.1476-5381.1968.tb00977.x
• Publication Date: 2012-07-20T20:00:09Z
• Authors: A. BENNETT; J. G. MURRAY; J. H. WYLLIE
• Keywords: Human stomach; Submucosa

Human stomach mucosa contains a pharmacologically active acidic lipid which is indistinguishable from (PGE2) prostaglandin E2 by chromatography in 2 different systems, and other tests. The concentrations present are of the order 1 mcg/g wet tissue. Concentrations similar body pyloric part stomach; much smaller amounts submucosa muscle. PGE2 acts directly on both longitudinal circular muscle layers human isolated stomach. contracted doses may be as low 2x10 -9 g/ml. In contrast, inhibits contractions caused acetylcholine or potassium.