Cannabidivarin is anticonvulsant in mouse and rat

• DOI: 10.1111/j.1476-5381.2012.02207.x
• Publication Date: 2012-09-12T12:00:15Z
• Authors: AJ Hill; MS Mercier; TDM Hill; SE Glyn; NA Jones; Y Yamasaki; T Futamura; M Duncan; CG Stott; GJ Stephens; CM Williams; BJ Whalley
• Keywords: Pilocarpine; Phenobarbital; Seizure threshold

Background and Purpose Phytocannabinoids in C annabis sativa have diverse pharmacological targets extending beyond cannabinoid receptors several exert notable anticonvulsant effects. For the first time, we investigated profile of phytocannabinoid cannabidivarin ( CBDV ) vitro vivo seizure models. Experimental Approach The effect (1–100 μM on epileptiform local field potentials LFPs induced rat hippocampal brain slices by 4‐aminopyridine (4‐ AP application or Mg 2+ ‐free conditions was assessed multi‐electrode array recordings. Additionally, (50–200 mg·kg −1 four rodent models: maximal electroshock mES audiogenic seizures mice, pentylenetetrazole PTZ pilocarpine‐induced rats. effects combination with commonly used antiepileptic drugs were investigated. Finally, motor side using static beam grip strength assays. Key Results significantly attenuated status epilepticus ‐like 4‐ conditions. had significant (≥100 ), (≥50 ‐induced ). (200 alone no against seizures, but these when administered valproate phenobarbital at this dose. function. Conclusions Implications These results indicate that is an effective a broad range Also it did not affect normal function and, therefore, merits further investigation as novel anti‐epileptic chronic epilepsy Linked Articles This article part themed section Cannabinoids. To view other articles visit http://dx.doi.org/10.1111/bph.2012.167.issue‐8