Antenatal Indomethacin‐Adverse Fetal Effects Confirmed

• DOI: 10.1111/j.1479-828x.1998.tb02949.x
• Publication Date: 2008-02-13T13:19:39Z
• Authors: Dereck Souter; Jane Harding; Lesley McCowan; Clare O'Donnell; Elisabeth McLeay; Helen Baxendale
• Keywords: Ductus arteriosus; Tocolytic agent; Tocolytic; Rupture of membranes; Indometacin

We examined the association between antenatal indomethacin exposure and adverse neonatal outcome in a matched retrospective cohort study of infants born to 72 mothers at less than 31 weeks' gestation. Indomethacin-exposed were controls by gestational age delivery, corticosteroid exposure, prolonged spontaneous rupture membranes, multiple pregnancy, thyrotrophin releasing hormone (TRH) sex. Periventricular haemorrhage was significantly increased for delivered within 48 hours maternal (Grade 1 2 19% versus 6%, Grades 3 4 28% 3% (p<0.03)). Persistent patent ductus arteriosus more common those (40% 20% (p<0.04)). More neonates exposed failed respond postnatal close arteriosus, 60% 0% (p<0.04). There no effects demonstrated administered greater from delivery. have confirmed probable administration an incidence periventricular haemorrhage, impaired renal function. The appear be greatest when is recommend that should used with caution as tocolytic agent treatment preterm labour gestations weeks.