The Effects of Human Amniotic Membrane and Fibrin Sealant in the Prevention of Postoperative Adhesion Formation in the Rabbit Ovary Model

• DOI: 10.1111/j.1479-828x.1998.tb03004.x
• Publication Date: 2008-02-13T13:16:12Z
• Authors: Semih Özeren; Aydin Çorakci; Ahmet Erk; Gulseren Yücesoy; Izzet Yücesoy; Onur Karabacak
• Keywords: Wound Healing; Biological Dressings; Ovary; Tissue Adhesions; Fibrin Tissue Adhesive; 3. Good health; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Pregnancy; Animals; Humans; Female; Rabbits

Summary: The study group consisted of 29 female, white New Zealand rabbits. The rabbits were randomized into 3 groups and a midline laparotomy was performed in order to make a 4–5 mm long lesion using a scalpel in both ovaries. In Group 1, both of the ovaries were left uncovered. In Group 2, the right ovaries were covered by human amniotic membrane graft. In Group 3, 0.1–0.2 mL of Tisseel solution was applied to the lesion in the right ovaries. No medication was applied to the left ovaries in any of the groups and thus this ovary acted as an individual control. After 2 weeks the adhesion scores were graded by relaparotomy in a blind manner. Fibrin sealant showed a significant reduction in postoperative adhesion formation compared with the amniotic membrane graft and control groups (p<0.001). Therefore, it can be concluded that fibrin sealant can be used as an adjuvant during reproductive surgery.