Predictors of Hippocampal, Cerebral, and Cerebellar Volume Reduction in Childhood Epilepsy

• DOI: 10.1111/j.1499-1654.2000.001540.x
• Publication Date: 2006-01-30T10:59:12Z
• Authors: John A. Lawson; Simon J. Vogrin; Andrew Bleasel; Mark Cook; Leah Burns; L E McAnally; John Pereira; Annie Bye
• Keywords: Abnormality; Febrile seizure

We examined the factors related to brain volume reduction in a pediatric sample of patients that included those with nonintractable epilepsy.Entry criteria were children less than 18 years old epilepsy referred for MRI, including whole volumetric sequence. The size was 231. Risk ascertained from interviews and reviews medical records. Factors age onset, seizure years, family history, status epilepticus, intellectual disability, febrile convulsions. MRI data obtained 44 normal childhood control subjects.Cerebral cerebellar volumes significantly associated age, gender, moderate-to-severe disability (p < 0.001), epilepticus 0.03). Compared controls, all reduced by 10% 0.001). Hippocampal total volume, focal cerebral ischemic injury, complex convulsions 0.05).Significant is present epilepsy. A component this due acquired insults. seen even infrequent seizures over brief time, suggesting an innate structural abnormality. When evaluating possible etiologic development hippocampal reduction, one must volume. have confirmed association unilateral reduction.