Efficacy and Safety of Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment of Melasma

• DOI: 10.1111/j.1524-4725.2011.02001.x
• Publication Date: 2011-05-26T13:26:11Z
• Authors: ZHOU XI; MICHAEL H GOLD; LU ZHONG; LI YING
• Keywords: Melasma; Neodymium; Nd:YAG laser; Laser Treatment

BACKGROUND Melasma is a common pigmentary disorder that affects all skin types but seen more in individuals with Fitzpatrick type IV to VI. Safe and effective treatment options for melasma need be explored. Already proven the of disorders, lasers have been used treat recent years. OBJECTIVE To evaluate efficacy safety profile 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (QS Nd:YAG) laser melasma. METHODS Fifty patients were recruited this study (47 female; 3 male). All treated using QS Nd:YAG at low energy levels weekly nine sessions. Follow-up was done months after final session, recurrence rates evaluated. Digital photographs taken melanin index (MI) measured before each visit treatment. Area Severity Index (MASI) scores evaluated patients. Patients required their satisfaction end treatments. We also confocal scanning microscope (CLSM) several investigate pathologic changes baseline, treatments, time recurrence. Statistical analysis performed clinical response factors related therapeutic outcome. RESULTS Mean MI decreased 35.8%, from 70.0 baseline 44.9 (p<.001). MASI 61.3% therapy (from 10.6–4.1, p<.001); 70% had than 50% decrease values, 10% 100% clearance. Recurrence rate 3-month follow-up 64%. CLSM findings indicated less regions, although it increased Multiple linear regression outcome depended on disease severity (p=.001, R=0.494). Minimal adverse events observed during study. CONCLUSIONS The an safe melasma, remain high, further adjunctive needs explored prevent loaned by Hamer Company (Guangzhou, Guangdong Province, China). Dr. Gold consultant to, speaker for, stock holder Lumenis.