In Vitro Effect of Nitazoxanide Against Entamoeba histolytica, Giardia intestinalis and Trichomonas vaginalis Trophozoites

• DOI: 10.1111/j.1550-7408.2002.tb00523.x
• Publication Date: 2005-07-11T18:07:52Z
• Authors: ROBERTO CEDILLO‐R...; BIBIANA CHÁVEZ; ARTURO GONZÁLEZ‐R...; AMPARO TAPIA; LILIÁN YÉPEZ‐MULIA
• Keywords: Nitazoxanide; Giardia; Giardia lamblia; Tritrichomonas foetus; Blastocystis; Cryptosporidium parvum; Albendazole; Antiprotozoal

ABSTRACT. Nitazoxanide, a 5‐nitrothiazolyl derivative, is effective in the treatment of broad range parasitic infections. In vitro, it active against several protozoa, including Cryptosporidiwn parvum, Blastocystis hominis , and Giardia intestinalis . The objective this study was to determine vitro effect nitazoxanide on growth morphology three anaerobic protozoa (Entamoeba histolytica, Trichomonas vaginalis ) compare these effects with those metronidazole albendazole. A subculture method used concentrations required inhibit by 50% or 90% (IC 50 IC 90 ). Nitazoxanide exhibited values 0.017 0.776 μg/ml respectively, E. histolytica 0.004 0.067 G. 0.034 2.04 6 T. Based values, more toxic than albendazole ; were most drug trophozoite ultrastructure all parasites included cell swelling distorted shape, redistribution vacuoles, plasma membrane damage, formation extensive empty areas cytoplasm protozoa.