Randomized Clinical Trial Comparing Two One-Week Triple-Therapy Regimens for the Eradication of Helicobacter pylori Infection and Duodenal Ulcer Healing

• DOI: 10.1111/j.1572-0241.1998.035_c.x
• Publication Date: 2005-01-06T09:32:35Z
• Authors: M Forné; J M Viver; M Esteve; F Fernandez-Banares; J Lite; J C Espinós; S Quintana; A Salas; J Garau
• Keywords: Rapid urease test; Intention-to-treat analysis

Objective: One-week triple therapy has been shown to be effective in Helicobacter pylori eradication and duodenal ulcer healing. However, the optimal therapeutic combination not yet identified. Bismuth-containing regimens have advantage of requiring only one antibiotic. It suggested that high doses omeprazole improve bactericidal efficacy antimicrobial against H. pylori. We evaluated two 1-wk triple-therapy for Methods: On an intention-to-treat basis, 182 patients with pylori-associated were randomized. Group OCB (n = 91) given 40 mg b.i.d., clarithromycin 500 colloidal bismuth subcitrate 120 q.i.d. 7 days. OCA treated at same plus amoxicillin 1 g also Endoscopies performed entry 4 wk after end treatment. The presence was assessed by urease test, histology, Gram stain, culture. No patient received follow-up Results: rates achieved groups similar whether (82.4% vs 88.9%; p 0.21) or per protocol analysis (83.3% 89.9%; 0.19). Duodenal healing intention-to treat (91.2% 91.1%) (92.2% 92.1%), respectively (p 0.98). Conclusions: High obtained both short-treatment regimens, which safe well-tolerated. Colloidal seems a good alternative clarithromycin. dose does seem play major role these combinations.