Dietary Inulin Improves Distal Colitis Induced by Dextran Sodium Sulfate in the Rat

• DOI: 10.1111/j.1572-0241.2001.03802.x
• Publication Date: 2004-03-29T10:34:12Z
• Authors: Sebastián Videla; Jaime Vilaseca; María Antolín; Ana García-Lafuente; Francisco Guarner; Ernesto Crespo; Jaume Casalots; Antonio Salas; Juan R. Malagelada
• Keywords: Cecum; Enema

Inulin stimulates intracolonic generation of butyrate and growth lactic acid bacteria. This study investigated whether inulin protects against colitis.Rats with dextran sodium sulfate colitis received either orally (1% in drinking water, or 400 mg/day) by enema. Matched groups vehicle. In addition, fecal water obtained from inulin-fed rats was administered enema to compared control rats. Finally, daily enemas (at 40 80 mmol/L) Inflammation assessed eicosanoid asssay rectal dialysates MPO activity colonic tissue. Mucosal lesions were blindly scored microscopic examination. Luminal pH measured cecum rectum a surface microelectrode.Oral prevented inflammation, as evidenced lower lesion scores (p < 0.05), decreased release mediators tissue 0.05) controls. induced acidic environment (pH <7.0) left colon increased counts lactobacilli. Fecal also reduced inflammation 0.05). However, had no effect.Oral reduces the severity colitis. The effect seems be mediated modification milieu.