Hypertransaminasemia in Pediatric Celiac Disease Patients and Its Prevalence as a Diagnostic Clue

• DOI: 10.1111/j.1572-0241.2002.07127.x
• Publication Date: 2004-03-23T15:12:28Z
• Authors: C. Farre; M. Esteve; A. Curcoy; E. Cabré; E. Arranz; L. L. Amat; S. Garcia-Tornel
• Keywords: Tissue transglutaminase; Gluten free

The aims of this study were to evaluate the following: 1) prevalence hypertransaminasemia (HT) in a pediatric celiac disease (CD) and its relation with clinical parameters; 2) frequency HT as only manifestation CD; 3) evolution after gluten free diet.A total 114 consecutive CD patients studied (60% classical 40% atypical forms). Antiendomisyum antibodies anti-tissue transglutaminase determined suspicion (including unexplained chronic HT), at risk, preoperative increased ALT activity for minor surgery. was confirmed by duodenal biopsy. At baseline, relationship between factors aminotransferase status univariately multivariately assessed. After starting diet, followed up, until serological markers cleared serum normalized.HT occurred 32% (37 114) diagnosis. five (4.3%). Patients younger (2.9 +/- 0.4 yr) than normal aminotransferases (5.1 0.5 (p = 0.007). A higher percentage tend have abnormal (73%; 95% CI 65-81%) do (27%; 19-35%) 0.068). Logistic regression analysis showed that age significantly associated 0.039; OR 0.8; 0.71-0.99). Aminotransferases normalized diet all 35 who followed-up, either before (n 18) or same time 17) cleared.HT is frequent finding and, substantial proportion, may be CD. Thus, should introduced first step diagnostic workup liver diseases patients.