Association of MICA-A5.1 allele with susceptibility to celiac disease in a family study

• DOI: 10.1111/j.1572-0241.2003.07228.x
• Publication Date: 2004-03-23T14:20:43Z
• Authors: B. Rueda; M. Pascual; M.A. Lopez-Nevot; B.P.C. Koeleman; E. Ortega; J. Maldonado; M. Lopez; J. Martin
• Keywords: Transmission disequilibrium test; Genetic Association; Genetic predisposition

The aim of this study was to analyze the role major histocompatibility complex class I chain-related gene A (MICA) transmembrane polymorphism in celiac disease (CD) susceptibility.Sixty-one Spanish families were genotyped for MICA by a polymerase chain reaction method combined with fluorescent technology. transmission disequilibrium test performed investigate preferential alleles affected offspring.The A5.1 allele shown be significantly transmitted siblings. This association independent CD-predisposing DQ2 haplotype. Additionally, we classified our into typical and atypical groups as found significant families. There also an tendency families.Our data suggest that is associated CD development independently DQ2-extended haplotype clinical forms CD.