Dermatological Manifestations in Primary Biliary Cirrhosis Patients: A Case Control Study

• DOI: 10.1111/j.1572-0241.2006.00423.x
• Publication Date: 2006-02-08T10:29:46Z
• Authors: Meri Koulentaki; Despina Ioannidou; Maria Stefanidou; Sofia Maraki; I. Drigiannakis; Philippas Dimoulios; Jean Marie Enele ...; Androniki Tosca; Elias A. Kouroumalis
• Keywords: Primary Biliary Cirrhosis

Primary biliary cirrhosis (PBC), a disease of probable autoimmune etiology that affects the small intrahepatic bile ducts mainly middle-aged women is commonly associated with pruritus, xanthomatous lesions, and melanosis. We conducted prospective study to systematically describe skin disorders group PBC patients.A evaluation analysis dermatological manifestations including oral genital lesions was carried out, in 49 patients (45 females 4 males). Median age 63 yr (range 35-87 yr). They were compared 45 sex matched controls, selected among persons attending dermatologic outpatient clinic.A total 330 found versus 76 controls; 31.5% all fungal infections. Of analyzed Bonferroni rule multiple comparisons significantly more common plantar mycoses, onychomycoses, interdigital mycoses. Pruritus 69.3% 22.2% xerosis 69.3%versus 2.2%, dermographism 57.1%versus 4.4%, melanosis 46.9%versus 0%. In 38.7% lesion presenting symptom.PBC present wide variety cutaneous varying severity. Multiple infections have been even early stages. Since than one third our sign or symptom leading diagnosis we believe physicians should be aware so prompt may achieved.