Usefulness of a Combined Evaluation of the Serum Adiponectin Level, HOMA-IR, and Serum Type IV Collagen 7S Level to Predict the Early Stage of Nonalcoholic Steatohepatitis

• DOI: 10.1111/j.1572-0241.2007.01322.x
• Publication Date: 2007-05-19T20:57:49Z
• Authors: Masahiko Shimada; Hiromu Kawahara; Kazuaki Ozaki; Masayuki Fukura; Hirokazu Yano; Mutsumi Tsuchishima; Mikihiro Tsutsumi; Shujiro Takase
• Keywords: Nonalcoholic steatohepatitis

Since nonalcoholic steatohepatitis (NASH) may progress to cirrhosis, it is important differentiate NASH from simple steatosis, especially in its early stages. However, a liver biopsy cannot be performed all patients with fatty disease (NAFLD). We herein investigated whether serum biochemical markers are useful for predicting early-stage NASH.Nineteen steatosis and 66 (stage 1-2 Brunt's criteria) were studied. The area under the receiver operating characteristic curve (AUC) was used illustrate diagnostic ability of parameters distinguish between NASH.The adiponectin level found significantly lower group (3.6 mug/mL) than (6.0 (P < 0.001). AUC high (0.765) group, also highest among other markers. sensitivity diagnosis 68%, which higher any factors, while specificity 79%. corresponding HOMA-IR 51% 95%, respectively. For type IV collagen 7S, 41% 95%. combination three 94%, 74%.Approximately 90% can predicted by combined evaluation level, HOMA-IR, 7S level.