Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis

• DOI: 10.1111/j.1600-0765.2011.01439.x
• Publication Date: 2011-12-20T02:33:50Z
• Authors: P. Mäntylä; E. Buduneli; G. Emingil; T. Tervahartiala; P. J. Pussinen; N. Barış; A. Akıllı; G. Atilla; T. Sorsa
• Keywords: Cathepsin G

There are indications that acute myocardial infarction (AMI) may have an effect on the oral environment, which is reflected in expression of salivary and gingival proteinases. According to our knowledge, no studies been carried out investigate AMI activities two major tissue-destructive serine protease microbial effectors, elastase cathepsin G, produced by fluid polymorphonuclear granulocytes (PMN). Therefore, we compared G saliva from patients with systemically healthy subjects (non-AMI) similar periodontal conditions.A total 92 (47 28 non-AMI gingivitis or periodontitis, 17 periodontally as a control group) were recruited. Clinical measurements recorded, stimulated whole-saliva samples collected. The clinically examined within 3-4 d after admission coronary care unit. neutrophil measured collection, at specific time-points during incubation (from baseline 23 h) synthetic peptide substrate assays.The periodontitis had significant trend for highest among study groups. Elastase correlated significantly each other group (r = 0.8, p < 0.01). In logistic regression analysis, level activity associated periodontitis.AMI be PMN saliva, despite its strong association periodontitis.