Effect of local anaesthetic infiltration with bupivacaine and ropivacaine on wound healing: a placebo‐controlled study

• DOI: 10.1111/j.1742-481x.2012.01101.x
• Publication Date: 2012-10-24T10:46:16Z
• Authors: João Abrão; Cleverson R Ferna...; Paul F White; Antonio C Shimano; Rodrigo Okubo; Giovanni BP Lima; José A Bachur; Sérgio B Garcia
• Keywords: Ropivacaine; Infiltration (HVAC)

Infiltration of surgical wounds with long‐acting local anaesthetics (LA) is used to reduce postoperative incisional pain. We hypothesised that infiltration LA interferes wound healing in rats. Seventy‐two rats were allocated into nine groups. After intraperitoneal anaesthesia, the interscapular dorsal region was infiltrated equivolumes saline, 0·5% bupivacaine or ropivacaine, a randomised double‐blind fashion. A standardised incision performed area and sutured closed. The euthanised on 3rd 14th day after operation tissue from site subjected histochemical analyses mechanical testing (MT). Compared control group, displayed significant increase macrophage number 3 (+63% versus +27% for ropivacaine). transforming growth factor β ‐1 expression had (versus saline) groups, +63% ropivacaine group +115% ( P < 0·05). collagen fibres as measured by dyed significantly higher (+56%, 0·01 +15% CD34 reduced (−51%, 0·05 +3% On 14, no statistical differences observed either respect histopathologic inflammatory mediators. MT 14 showed between saline LA‐induced increases histological markers did not extend beyond third day, suggesting does impair process