Evaluation of a 6‐Month Chemotherapy Protocol with No Maintenance Therapy for Dogs with Lymphoma

• DOI: 10.1111/j.1939-1676.2002.tb02411.x
• Publication Date: 2009-05-06T14:43:40Z
• Authors: Laura D. Garrett; Douglas H. Thamm; Ruthanne Chun; Robert Dudley; David M. Vail
• Keywords: Canine Lymphoma; Univariate analysis; Maintenance therapy

The purpose of this study was to compare a maintenance‐free chemotherapy protocol based on CHOP (H from hydroxydaunorubicin = doxorubicin, O Oncovin®= vincristine) similar with maintenance phase for the treatment canine lymphoma. Fifty‐three dogs multicentric lymphoma were treated 6‐month modified version University Wisconsin (UW)‐Madison (UW‐25). Disease‐free interval (DFI) and survival compared historical control group 55 prolonged phase. Remission rate 94.2% (complete remission 92.3%, partial 1.9%). DFI between 2 groups did not differ significantly, median equal 282 397 days 220 303 ( P .2835 .3365, respectively). Univariate analysis identified substage b .0087), German Shepherd breed .0199), body weight > 18 kg .0016) as significant worse survival. Longer associated thrombocytopenia .0436). Multivariate revealed that .0388) .0125) retained significance DFI, whereas .0093), .0150), 0 .0050) Overall, well tolerated by dogs, 41.5% (22/53) requiring delay or dose modification, but only 9.4% (5/53) needing hospitalization. no provides times when