Associations of E‐proteinoid 3 receptor genetic polymorphisms with salt sensitivity, longitudinal blood pressure changes, and hypertension incidence in Chinese adults

• DOI: 10.1111/jch.14859
• Publication Date: 2024-07-02T05:45:31Z
• Authors: Ming‐Ke Chang; Guan‐Ji Wu; Peng Bao; Shi Yao; Ming‐Fei Du; Chao Chu; Dan Wang; Hao Jia; Yue Sun; Yu Yan; Xi Zhang; Gui‐Lin Hu; Zi‐Yue Man; Tong‐Shuai Guo; Wen‐Jing Luo; Hao Li; Yang Wang; Jian‐Jun Mu
• Keywords: SNP; Longitudinal Study

Abstract The E‐proteinoid 3 receptor (PTGER3), a member of the prostaglandin E2 (PGE2) subtype receptor, belongs to G‐protein‐coupled superfamily receptors. Animal studies have demonstrated its involvement in salt sensitivity by regulating sodium reabsorption. This study aimed investigate association between genetic variants PTGER3 and sensitivity, longitudinal blood pressure (BP) changes, incidence hypertension Chinese adults. A chronic intake intervention was conducted involving 514 adults from 124 families 2004 Baoji Salt‐Sensitivity Study Cohort northern China. These participants followed 3‐day regular baseline diet, 7‐day low‐salt diet (3.0 g/d) high‐salt (18 g/d), were subsequently for 14 years. findings revealed significant relationship single nucleotide polymorphism (SNP) rs17482751 diastolic (DBP) response high intervention. Additionally, SNPs rs11209733, rs3765894, rs2268062 significantly associated with changes systolic (SBP), DBP, mean arterial (MAP) during 14‐year follow‐up period. SNP rs6424414 DBP over Finally, showed correlation results emphasize role gene BP development population.