Hepatocyte growth factor alleviates hepatic insulin resistance and lipid accumulation in high‐fat diet‐fed mice

• DOI: 10.1111/jdi.12904
• Publication Date: 2018-08-03T13:20:02Z
• Authors: Yali Jing; Qingmin Sun; Xiaolu Xiong; Ran Meng; Sunyinyan Tang; Shu Cao; Yan Bi; Dalong Zhu
• Keywords: Lipid Accumulation; Fat accumulation

Type 2 diabetes mellitus is frequently accompanied by fatty liver disease. Lipid accumulation within the considered as one of risk factors for insulin resistance. Hepatocyte growth factor (HGF) used to treat dysfunction; however, effect and mechanism HGF on hepatic lipid metabolism are still not fully understood.Male C57BL/6 mice were induced with a high-fat diet 12 weeks, followed 4-week treatment or vehicle saline. The levels fasting blood glucose, homeostatic model assessment resistance calculated sensitivity. Biochemical plasma parameters also measured assess accumulation. Additionally, genes in pathway evaluated palmitic acid-treated HepG2 cells mice.HGF significantly decreased triglyceride cholesterol contents. HGF-regulated expression sterol regulatory element-binding protein-1c/fatty acid synthase, peroxidase proliferator-activated receptor-α, upstream nuclear receptors, such farnesoid X receptor small heterodimer partner. Furthermore, c-Met inhibitor could partially reverse effects HGF.HGF can ameliorate steatosis through regulation metabolism. These might occur receptor-small partner axis-dependent transcriptional activity.