Microvascular permeability and texture analysis of bone marrow in diabetic rabbits with critical limb ischemia based on dynamic contrast‐enhanced magnetic resonance imaging

• DOI: 10.1111/jdi.14145
• Publication Date: 2024-01-19T12:44:50Z
• Authors: Liu Yang; Donghang Li; Yuchen Yan; Qi Yang; Liang Li; Yunfei Zha
• Keywords: Microvessel; Vascular permeability

ABSTRACT Background Early on in the development of diabetes, skeletal muscles can exhibit microarchitectural changes that be detected using texture analysis (TA) based volume transfer constant ( K trans ) maps. Nevertheless, there have been few studies and thus we evaluated microvascular permeability TA bone marrow diabetics with critical limb ischemia (CLI). Methods Eighteen male rabbits were randomly assigned equally into an operation group hindlimb a sham‐operated diabetes only, control group. Dynamic contrast enhanced magnetic resonance imaging (DCE‐MRI) was performed all at predetermined intervals (1, 5, 10, 15, 20, 25 days post‐surgery). The pharmacokinetic model used to generate parameters, while textural parameters derived from map. Data methods included independent sample t ‐test, Mann–Whitney U test, repeated‐measures variance, Pearson correlation tests. Results values reached minimum day 1 after induction, then gradually recovered, but remained lower than those fraction only showed significant difference between 5 post‐surgery, not extravascular extracellular space time points. A significantly reduced 1, decreased number trabeculae (Tb.N), area (Tb.Ar), increased microvessel density compared observed. At each point, discernible two groups mean value, positive pixels, sum Average . Conclusions early stages diabetic CLI by DCE‐MRI for permeability. Texture could act as discriminator new radiological tool mellitus.