Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019–2022 prospective study with cluster and network analysis

• DOI: 10.1111/jdv.19934
• Publication Date: 2024-02-27T13:40:12Z
• Authors: David Pesqué; Leopoldo Borrego; Violeta Zaragoza‐...; Tatiana Sanz‐Sánchez; Francisco Javier ...; Ricardo González‐...; Juan Francisco Si...; Susana Córdoba‐Gu...; José Manuel Carra...; María Elena Gatic...; Inmaculada Ruiz‐G...; Pedro Mercader‐Ga...; Fátima Tous‐Romero; Francisco Javier ...; Esther Serra‐Bald...; María Antonia Pas...; Mercedes Rodrígue...; Javier Sánchez‐Pérez; Araceli Sánchez‐Gilo; Gemma Melé‐Ninot; Paloma Sánchez‐Pe...; Ramon Maria Pujol; Ana María Giménez...
• Keywords: Clinical Significance

Abstract Background There is still limited clinical‐practice data on specific clinical and patch test features, as well allergen clusters in polysensitization (PS). Objectives To determine the frequency, relevance, symptoms duration risk factors polysensitized patients to assess possible aggregation. Methods Prospective multicentric study (January 2019–December 2022) conducted setting of Spanish Contact Dermatitis Register (REIDAC). Clinical oligosensitized were compared, PS investigated with logistic multivariate regression. Unsupervised hierarchical clustering network analysis used aggregation PS. Results A total 10,176 analysed. was found 844 (8.3%). Current relevance significantly higher ( p < 0.01). Risk for atopic dermatitis (OR: 1.58, 95% CI: 1.24–2.02), age (≥60 years vs. ≤24 years, OR: 1.75, 1.25–2.44) some special locations (legs face 1.54, 1.05–2.25, hands 1.46, CI:1.15–1.85, arms 1.49, CI:1.01–2.20, trunk 1.40, CI:1.06–1.85). Cluster analyses revealed specific‐allergen significant associations, including allergens belonging metals group, fragrances botanicals topical drugs rubber biocides. Conclusions This confirms that structured by discernible patterns reinforces associations Cross‐reactivity and/or concomitant sensitization could explain formation