Downregulation of serotonin reuptake transporter gene expression in healing colonic mucosa in presence of remaining low‐grade inflammation in ulcerative colitis

• DOI: 10.1111/jgh.13268
• Publication Date: 2015-12-17T14:52:44Z
• Authors: Yasumasa Tada; Shunji Ishihara; Kousaku Kawashima; Nobuhiko Fukuba; Hiroki Sonoyama; Ryusaku Kusunoki; Akihiko Oka; Yoshiyuki Mishima; Naoki Oshima; Ichiro Moriyama; Takafumi Yuki; Noriyoshi Ishikawa; Asuka Araki; Yuji Harada; Riruke Maruyama; Yoshikazu Kinoshita
• Keywords: Intestinal mucosa; Pathogenesis

Abstract Background and Aim The serotonin reuptake transporter (SERT) terminates activity by removing it from interstitial space. Downregulated colonic SERT expression has been reported in irritable bowel disease (IBS), symptoms resembling IBS occur cases of inflammatory (IBD) remission; thus, a common pathogenesis for IBD is possible. However, little known regarding mucosa patients during healing. Methods Twenty‐two ulcerative colitis (UC) underwent colonoscopy examinations, which inflamed was distinguished that undergoing Healing classified into regular irregular vessel patterns narrowband imaging magnifying colonoscopy. Expressions various inflammation‐related genes biopsy samples were assessed using polymerase chain reaction array system real‐time reaction. Colitis model mice established administration dextran sodium sulfate or transfer CD4 + T cells isolated SAMP1 mice, then time‐course changes gene expressions observed mucosa. Results In UC patients, significantly lower than healing decreased with an pattern mildly increased levels expression. suppressed continuously low‐grade mucosal inflammation Conclusions Sserotonin downregulated suppression may be dependent on the presence remaining inflammation.