Determining the usefulness of Capsule Scoring of Ulcerative Colitis in predicting relapse of inactive ulcerative colitis

• DOI: 10.1111/jgh.15220
• Publication Date: 2020-08-28T11:19:25Z
• Authors: Mao Matsubayashi; Taku Kobayashi; Shinji Okabayashi; Masaru Nakano; Shintaro Sagami; Ryo Ozaki; Hiroki Kiyohara; Hiromu Morikubo; Kunio Asonuma; Yusuke Miyatani; Shin Maeda; Toshifumi Hibi
• Keywords: White blood cell; Lactoferrin; Erythrocyte sedimentation rate; Univariate analysis

Abstract Background and Aim The usefulness of second‐generation colon capsule endoscopy (CCE2) in ulcerative colitis (UC), especially clinically inactive patients, has been reported. Capsule Scoring Ulcerative Colitis (CSUC) was developed as a severity index for UC. We aimed to determine whether CSUC is useful predicting relapse during clinical remission. Methods Forty‐one UC patients remission who underwent CCE2 were prospectively registered from April 2016 August 2019. Patients' score obtained; those with subsequent followed up retrospectively. correlation white blood cell count, platelet albumin, C‐reactive protein, fecal calprotectin lactoferrin levels, immunochemical test results evaluated; their predictive values future compared. Results correlations cell, platelet, calprotectin, test, r s = 0.13, 0.27, −0.25, 0.15, 0.50, 0.43, respectively. higher 12 relapsed within 1 year than 29 remained (2.83 ± 1.95 vs 0.72 1.00, P < 0.01). Receiver operator characteristic curve analysis showed that ≥ predictor (area under the 0.82, sensitivity 83.3%, specificity 58.6%) maybe superior biomarkers. In univariate analysis, 0 had lower rate ≧ ( 0.03, log–rank test). After analyzing 6 months after successful induction treatment, ≤ year. Conclusion predicts remission, when used treatment.