Glyphosate and glyphosate‐based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome

• DOI: 10.1111/jne.12731
• Publication Date: 2019-05-08T00:39:12Z
• Authors: Julie Dechartres; Jodi L. Pawluski; Marie‐Madeleine G...; Amin Jablaoui; Emmanuelle Maguin; Moez Rhimi; Thierry D. Charlier
• Keywords: 570; Glyphosate; Doublecortin Protein; hippocampus; [SDV]Life Sciences [q-bio]; Neurogenesis; neuroplasticity; Glycine; 610; Hippocampus; Rats, Sprague-Dawley; 03 medical and health sciences; Peripartum Period; Animals; [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology; [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; Maternal Behavior; Cell Proliferation; [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism; Neurons; 0303 health sciences; Neuronal Plasticity; gut microbiota; Herbicides; [SDV.BA]Life Sciences [q-bio]/Animal biology; cingulate gyrus; [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism; Gastrointestinal Microbiome; 3. Good health; [SDV] Life Sciences [q-bio]; neurogenesis; [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology; [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]; Female; neuroplasticity.

Glyphosate is found in a large array of non-selective herbicides such as Roundup® (Monsanto, Creve Coeur, MO, USA) and by far the most widely used herbicide. Recent work rodent models suggests that glyphosate-based during development can affect neuronal communication result altered behaviours, albeit through undefined mechanisms action. To our knowledge, no study has investigated effects glyphosate or its formulation herbicide on maternal behaviour physiology. In present study, relatively low doses (5 mg kg-1 d-1 ), equivalent), vehicle were administered ingestion to Sprague-Dawley rats from gestational day (GD) 10 postpartum (PD)22. The treatments significantly licking toward pups between PD2 PD6. We also show dams at PD22 Roundup exposure affected maturation doublecortin-immunoreactive new neurones dorsal dentate gyrus hippocampus mother. addition, expression synaptophysin was up-regulated ventral CA3 regions hippocampus, down-regulated cingulate gyrus. Although direct effect alone central nervous system currently not clear, we gut microbiota pesticides, with significant alteration phyla Bacteroidetes Firmicutes. This first provide evidence (Roundup) differentially affects modulates neuroplasticity