Assessment of the efficacy and tolerance of a new combination of retinoids and depigmenting agents in the treatment of melasma

• DOI: 10.1111/jocd.12110
• Publication Date: 2014-11-17T05:26:21Z
• Authors: Maria Teresa Truc...; Natalia Jiménez; Pedro Jaén
• Keywords: Melasma

Summary Background Melasma is a dermatosis with significant repercussions on patients' quality of life, and there currently no standard treatment. Hydroquinone deemed the treatment choice, but its safety has been questioned in certain cases. Aims To determine efficacy new combination retinoids improvement melasma. Patients/Methods Prospective, double‐blind, vehicle‐controlled, randomized study 30 patients The product was applied one side face vehicle other, twice daily during 3 months. Standardized photographs were taken using RBX technology three visits (basal, at half months months). main variable to hemifacial Area Severity Index ( MASI ). Other variables determined such as perceived by investigator, patient, impact life or effects. Results treated vs . side, reaching an 70%, which comparable percentage described hydroquinone. No notable effects detected, spite included citing history that could be compatible sensitive skin. Conclusions This depigmenting agents proved effective safe