Resolve and dissolve—An ultrasound‐guided investigation on the effects of hyaluronidase on different soft tissue fillers

• DOI: 10.1111/jocd.16393
• Publication Date: 2024-05-21T04:40:11Z
• Authors: Bruna S. F. Bravo; Thamires Cavalcante; Camila Silveira; Leonardo G. Bravo; Maria Carolina Zafra; Mariana Calomeni ...
• Keywords: Hyaluronidase

Abstract Background Nonsurgical cosmetic procedures, particularly the use of hyaluronic acid (HA)‐based soft tissue fillers, are becoming increasingly popular. This trend has catalyzed development a plethora HA‐based products differing in product characteristics, thereby catering to an ever‐widening spectrum aesthetic applications. However, complications rise concomitant with increasing number procedures. Among strategies manage such adverse events is enzymatic breakdown hyaluronidase. Objective To analyze response different filler materials hyaluronidase injections. Methods A total 11 fillers were evaluated using noninvasive ultrasound imaging assess their behavior The categorized according characteristics into structuring, volumizing, and lip volumizing group. Standardized injections 0.2 cc performed chicken breast simulate human tissue. Ultrasound measurements width, height, calculated volume immediately after injection, 1 h 24 following injection. Results Regardless analyzed, most significant reduction occurred within first applying hyaluronidase, 64.1% decrease from initial volume. After h, reached 81.7%. No statistically differences found when comparing three groups at each follow‐up time period, except for height measurement h. While width was all between investigated groups, only highest second G' values (i.e., Group 1—structuring, 2—volumizing). Conclusion effectiveness dissolving initially independent as G‐prime, increased efficacy higher G‐prime values, evidenced by reductions groups.