A study of clinicopathologic factors as indicators for early prediction of suboptimal debulking surgery after neoadjuvant chemotherapy in advanced ovarian cancer

• DOI: 10.1111/jog.13653
• Publication Date: 2018-04-23T10:28:26Z
• Authors: Joo‐Hyuk Son; Kyoungjin Chang; Tae‐Wook Kong; Jiheum Paek; Suk‐Joon Chang; Hee‐Sug Ryu
• Keywords: Debulking

This study aimed to evaluate early clinicopathologic factors predicting gross residual disease after neoadjuvant chemotherapy in patients with advanced epithelial ovarian cancer.We analyzed data of 68 cancer who were treated followed by interval debulking surgery (NAC-IDS) between March 2006 and December 2016. All the received three cycles NAC IDS. We evaluated all possible characteristics, including reduction rates serum CA-125 each seven initial abdominopelvic computed tomography (CT) findings related severity.After IDS, no was found 46 (67.6%) 22 (33.4%) had disease. Multivariate analysis identified that rate 2nd NAC, body mass index (BMI) small bowel lesion CT significantly associated IDS (P = 0.005, 0.030, 0.001, respectively). The optimal cutoff value less than 50% low BMI (<23 kg/m2 ). combined receiver operating characteristic curve these showed good performance for (area under 0.845).A model using mesentery involvement on CT, ) level is highly predictive patients. These results may be helpful further treatment planning counseling.