Increased risk for microvascular outcomes in NAFLD—A nationwide, population‐based cohort study

• DOI: 10.1111/joim.13673
• Publication Date: 2023-06-01T05:03:40Z
• Authors: Thomas Ebert; Linnea Widman; Peter Stenvinkel; Hannes Hagström
• Keywords: Cohort Studies; Liver Cirrhosis; Diabetes Mellitus, Type 2; Non-alcoholic Fatty Liver Disease; Risk Factors; Humans; Risk Assessment; 3. Good health

Nonalcoholic fatty liver disease (NAFLD) is considered a multisystem disease, as it bidirectionally linked to other cardiometabolic disorders, such type 2 diabetes (T2D). However, the long-term risk for microvascular outcomes in NAFLD unclear.Using outpatient part of nationwide Swedish Patient Register time period between 01/01/2002 and 12/31/2019, we identified all individuals with first diagnosis (N = 6785) matched these (age, sex, municipality) up 10 reference from general population 61,136). Using population-based registers, ascertained development diseases. The primary outcome was defined composite any representative (chronic kidney retinopathy, or neuropathy). As secondary outcomes, separately examined each specific outcome. Hazard ratios (aHR, adjusted cirrhosis time-varying T2D, hypertension, hyperlipidemia) were calculated by Cox proportional-hazards models.Median follow-up 5.7 years. incidence rate diseases >twofold higher patients (10.8 per 1000 person-years [95% confidence interval (CI) 9.9-11.8]) versus (4.7 [95%CI 4.5-4.9]). independently positively associated compared non-NAFLD subjects (aHR 1.45 1.28-1.63]). When stratifying analysis time, age categories, results remain virtually unchanged.NAFLD should be taken into account personalized assessment NAFLD.