Differentiation of hemangioblastoma from brain metastasis using MR amide proton transfer imaging

• DOI: 10.1111/jon.13019
• Publication Date: 2022-06-22T14:13:22Z
• Authors: Kiyohisa Kamimura; Masanori Nakajo; Misaki Gohara; Kodai Kawaji; Manisha Bohara; Yoshihiko Fukukura; Hiroyuki Uchida; Kazuhiro Tabata; Takashi Iwanaga; Yuta Akamine; Jochen Keupp; Tomoaki Fukami; Takashi Yoshiura
• Keywords: Hemangioblastoma; Amide

Differentiation between hemangioblastoma and brain metastasis remains a challenge in neuroradiology using conventional MRI. Amide proton transfer (APT) imaging can provide unique molecular information. This study aimed to evaluate the usefulness of APT differentiating hemangioblastomas from metastases compare with diffusion-weighted dynamic susceptibility contrast perfusion-weighted imaging.This retrospective included 11 patients 20 metastases. Region-of-interest analyses were employed obtain mean, minimum, maximum values signal intensity, apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), these indices compared unpaired t-test Mann-Whitney U test. Their diagnostic performances evaluated receiver operating characteristic (ROC) analysis area under ROC curve (AUC). AUCs DeLong's method.All MRI-derived significantly higher than metastasis. revealed best performance APT-related (AUC = 1.000), although pairwise comparisons showed no significant difference mean ADC rCBV.APT is useful robust tool for