HepatitisCdisease burden and strategies to manage the burden (Guest Editors Mark Thursz, Gregory Dore and John Ward)

• DOI: 10.1111/jvh.12253
• Publication Date: 2014-04-09T03:41:29Z
• Authors: G. J. Dore; J. Ward; M. Thursz
• Keywords: Hepatitis C; Liver disease; Global Health

Summary Chronic hepatitis C virus ( HCV ) infection leads to liver fibrosis, cirrhosis and hepatocellular carcinoma HCC ). The recent Global Burden of Disease project estimated that in 2010 among 170 million people living with chronic , an 483 100 died from ‐related failure or . last two decades has seen progressive improvements treatment the most therapies offering simple, tolerable, short‐duration therapy extremely high efficacy. development public health strategies addressing emerging epidemics requires sound epidemiological data. This study covers data collection, detailed expert opinion input country‐specific mathematical modelling epidemic potential impact improved 16 countries. analysis demonstrates vary considerably terms age distribution infected population across In addition, burden advanced disease varies widely. is dependent upon factors including prevalence, (and duration infection) those infected, prevalence cofactors for progression (particularly heavy alcohol intake) uptake success therapeutic intervention. Introduction new assumed sustained virological response SVR rate >90% will have a modest on projected burden. A combination enhanced efficacy greater population‐level However advocacy both private sector investment are required demonstrate significant reduction