Metabolic and Endocrine Profiles in Sick Neonatal Foals Are Related to Survival

• DOI: 10.1111/jvim.12064
• Publication Date: 2013-03-25T19:43:40Z
• Authors: L. Armengou; E. Jose‐Cunilleras; J. Ríos; C. Cesarini; J. Viu; L. Monreal
• Keywords: Hypertriglyceridemia; Male; Cavalls; 0402 animal and dairy science; CIRCI; 04 agricultural and veterinary sciences; Cries; Prognosis; 3. Good health; Neonatal septicemia; Animals, Newborn; Sepsis; Malalties; Odds Ratio; Animals; Female; Horse Diseases; Horses

Background Sick neonatal foals suffer from a variety of endocrine and metabolic derangements that may be related to outcome. There are several hepatic lipid metabolism blood markers have never been assessed in foals. Objectives Assess panel variables group sick healthy order describe their relationship with diagnosis survival. Animals All referred Unitat Equina‐Fundació Hospital Clínic Veterinari during 3 consecutive foaling seasons Methods Observational prospective study. Blood samples were obtained on admission and, when possible, after 24–48 h hospitalization immediately before discharge or death. Measured triglycerides, nonsterified fatty acids, glucose, creatinine, urea, γ‐glutamyltransferase, glutamate dehydrogenase ( GLDH ), insulin, cortisol, bile adrenocorticotropic hormone ACTH ). /cortisol glucose/insulin ratios calculated. Results Urea, cortisol had median concentrations septic nonseptic 2‐ 8‐fold higher than the control P < .001). Median concentration was approximately 4 times ratio significantly lower compared A score designed including , cortisol. When ≥2 these altered .001), foal 32 more risk dying OR 31.7; 95% CI 7.7–130.3). Conclusions Clinical Importance Plasma should determined newborn because association