Oral Cobalamin Supplementation in Dogs with Chronic Enteropathies and Hypocobalaminemia

• DOI: 10.1111/jvim.13797
• Publication Date: 2015-12-10T08:26:39Z
• Authors: L. Toresson; J.M. Steiner; J.S. Suchodolski; T. Spillmann
• Keywords: Male; DIAGNOSIS; THERAPY; 0403 veterinary science; Veterinary science; Dogs; Animals; Dog Diseases; Oral supplementation; Retrospective Studies; METHYLMALONIC ACID CONCENTRATIONS; SERUM COBALAMIN; Vitamin B12; VITAMIN B12; Inflammatory Bowel Disease; Vitamin B 12 Deficiency; 04 agricultural and veterinary sciences; OPEN-LABEL; 3. Good health; DEFICIENCY; Intestinal Diseases; Vitamin B 12; PERNICIOUS-ANEMIA; Chronic Disease; Female; SMALL ANIMAL; INFLAMMATORY-BOWEL-DISEASE; INTRINSIC-FACTOR

Background Cobalamin deficiency is commonly associated with chronic enteropathies ( CE ) in dogs and current treatment protocols recommend parenteral supplementation. In humans, several studies have reported equal efficacy of oral cobalamin administration cobalamin. Objectives To retrospectively evaluate whether supplementation can restore normocobalaminemia hypocobalaminemia. Animals Fifty ‐ one client‐owned various signs Material Methods Retrospective study based on a computerized database search for treated at Evidensia Specialist Animal Hospital, Helsingborg, Sweden during January 2012–March 2014. Inclusion criteria were , an initial serum ≤270 ng/L (reference interval: 234–811 ng/L) tablets. Serum follow‐up was analyzed 20–202 days after continuous started. Results All became normocobalaminemic The mean increase concentration 794 ± 462 ng/L. concentrations significantly higher (mean 1017 460 ng/L; P < .0001) than baseline 223 33 ng/L). Conclusion Clinical Importance Our results suggest that effective normalizing . Prospective comparing cellular status being versus are warranted before be recommended routine