A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs

• DOI: 10.1111/jvim.16985
• Publication Date: 2024-01-11T10:44:20Z
• Authors: Marjory B. Brooks; Robert Goggs; Amelia H. Frye; Jessica Armato; Marnin Forman; Julia Hertl; Michael Koch; John P. Loftus; John Lucy; Brandi Mattison; Julia Merriam; Sarah Shropshire; Laura Van Vertloo; Austin Viall; Dana N. LeVine
• Keywords: Hematology

Abstract Background Primary immune thrombocytopenia (pITP) in dogs presents a diagnostic challenge, and clinical markers of severity are lacking. Objectives Identify clinicopathologic features that differentiate pITP from secondary ITP (sITP) related to bleeding severity, transfusion, survival with pITP. Animals Ninety‐eight thrombocytopenic (58 40 sITP). Methods Client‐owned platelet counts <50 000/μL were enrolled prospective, multi‐institution cohort study. History treatment information, through maximum 7 days, was recorded on standard data forms. Bleeding scored daily using assessment tool (DOGiBAT). At‐admission blood samples collected for CBC, biochemistry, C‐reactive protein concentration, coagulation panels, measure surface‐associated immunoglobulin G (PSAIg) expression membrane proteins phospholipids. Dogs evidence coincident disease classified as sITP. Results No definitive test found. However, cases characterized by lower counts, D dimer concentrations, than sITP cases. Differentiation between further enhanced logistic regression modeling combining patient sex, profile, count, dimer, PSAIg. A second model indicated low hematocrit high BUN concentration associated non‐survival. Low at admission, but not count or DOGiBAT score, transfusion. Conclusions Clinical Importance Pending validation studies, models constructed at‐admission findings may improve differentiation identify the most severe time presentation.