Intestinal inflammation, oxidative damage, and pathogenesis of intestinal Cryptosporidium in juvenile Asian sea bass (Lates calcarifer)

• DOI: 10.1111/jwas.13114
• Publication Date: 2024-10-18T05:35:44Z
• Authors: Sasibha Jantrakajorn; Narissara Keawchana; Peerapon Sornying; Pokphon Khirilak; Watcharapol Suyapoh
• Keywords: Sea bass; Pathogenesis; Barramundi

Abstract Piscine intestinal Cryptosporidium infection is a known cause of severe illness and mortality in juvenile Asian sea bass, with inflammation playing central role. This triggers the generation reactive oxygen species (ROS), leading to irreversible DNA damage activation apoptosis pathways. However, specific impact on ROS production, damage, this context remains unclear. study investigated pathogenic role causing cell piscine cryptosporidiosis. Forty‐four samples from 60‐ 90‐day bass were divided into four groups based status. Histopathological evaluation immunofluorescent analysis conducted assess cellular markers. Results showed significantly higher inflammatory infiltration, intracellular 60‐day infected fish compared fish. These findings underscore distinct responses cryptosporidiosis, highlighting inflammation, oxidative apoptosis, particularly younger