Direct antiviral agent treatment of chronic hepatitis C results in rapid regression of transient elastography and fibrosis markers fibrosis‐4 score and aspartate aminotransferase‐platelet ratio index

• DOI: 10.1111/liv.13256
• Publication Date: 2016-09-28T08:47:10Z
• Authors: Jacqueline A. Bac...; Piero V. Valli; Arne Kröger; Irina Bergamin; Patrizia Künzler; Adriana Baserga; Dominique Braun; Burkhardt Seifert; Anja Moncsek; Jan Fehr; David Semela; Lorenzo Magenta; Beat Müllhaupt; Benedetta Terziro...; Joachim C. Mertens
• Keywords: Transient elastography; Concordance

Novel direct antiviral agents (DAA) targeting hepatitis C virus (HCV) have revolutionized the treatment of chronic infection (CHC). Rates sustained virological response (SVR) to drastically improved since introduction DAA. Transient Elastography (TE) is an ultrasound based, non-invasive technique assess liver stiffness (LS). We examined changes in TE values and fibrosis scores FIB-4 APRI after DAA CHC.549 patients who received a based for CHC were screened 392 included. recorded prior therapy within 18 months evaluated. In addition, calculated histopathological results if available.Median was 12.65 kPa (IQR 9.45-19.2 kPa) decreased 8.55 5.93-15.25) post-treatment. This finding statistically significant (P<.001) equals regression 32.4% treatment. Median significantly from 2.54 1.65-4.43) 1.10 0.65-2.43) 1.80 1.23-2.84, P<.001) 0.43 0.3-0.79, respectively.Patients with SVR showed values. Rapid decrease concordance validated APRI. It remains be whether this indicates true or merely resolution inflammation subsequent improvement laboratory parameters.