Epitranscriptome machinery in Trypanosomatids: New players on the table?

• DOI: 10.1111/mmi.14688
• Publication Date: 2021-01-29T19:29:55Z
• Authors: Suellen Rodrigues...; João Luiz de Lemo...; Crhisllane Rafael...; Suzanne M. McDermott; Antonio Mauro Rez...; Nilmar Silvio Mor...
• Keywords: Pseudouridine

Trypanosoma and Leishmania parasites cause devastating tropical diseases resulting in serious global health consequences. These organisms have complex life cycles with mammalian hosts insect vectors. The must, therefore, survive different environments, demanding rapid physiological metabolic changes. responses depend upon regulation of gene expression, which primarily occurs posttranscriptionally. Altering the composition or conformation RNA through nucleotide modifications is one posttranscriptional mechanism regulating fate function, including N6-methyladenosine (m6A), N1-methyladenosine (m1A), N5-methylcytidine (m5C), N4-acetylcytidine (ac4C), pseudouridine (Ψ), dynamically regulate stability translation diverse organisms. Little known about their machinery Trypanosomatids, but we hypothesize that they parasite expression are vital for survival. Here, identified Trypanosomatid homologs writers m1A, m5C, ac4C, Ψ analyze evolutionary relationships. We systematically review evidence functions assess potential use as therapeutic targets. This work provides new insights into roles these proteins biology treatment illustrates Trypanosomatids provide an excellent model system to study modifications, molecular, cellular, biological consequences, interplay.