Acute kidney injury in rats with or without pre‐existing chronic kidney disease: Cytokine/chemokine response

• DOI: 10.1111/nep.12263
• Publication Date: 2014-04-15T07:52:51Z
• Authors: Martin Skott; Rikke Nørregaard; Hanne Birke‐Sørensen; Johan Palmfeldt; Tae‐Hwan Kwon; Jørgen Frøkiær; Søren Nielsen
• Keywords: Albuminuria

Abstract Aim Evidence suggests the possibility that pre‐existing chronic kidney ( CKD ) disease may result in a more severe outcome of acute injury AKI ). The aim this study was to examine whether enhances inflammatory response kidney, as well other organs, rats. Methods induced by 5/6 nephrectomy Nx and intestinal ischaemia reperfusion IIR Results For 6 weeks following there progressive increase serum creatinine with associated development albuminuria. increment above baseline determination 90 min comparable sham . Similarly, increased levels alanine transaminase histomorphological changes lungs were observed rats exposed compared those , no additional significant impact In tissue cytokines/chemokines equally elevated regardless exposure or lung liver Conclusion We conclude immediate severity is similar without However, on cytokine/chemokine after not uniform tissue.