Dopamine and ghrelin receptor co‐expression and interaction in the spinal defecation centers

• DOI: 10.1111/nmo.14051
• Publication Date: 2020-12-02T22:45:48Z
• Authors: John B. Furness; Ruslan V. Pustovit; Andrew J. Syder; Mitchell T. Ringuet; Eun Ji Yoo; Andrea Fanjul; Jill Wykosky; Linda J. Fothergill; Emily A. Whitfield; Sebastian G. B. F...
• Keywords: Quinpirole

Abstract Background Dopamine receptor 2 (DRD2) and ghrelin (GHSR1a) agonists both stimulate defecation by actions at the lumbosacral center. is in nerve terminals surrounding autonomic neurons of center, whereas not present spinal cord. D2 receptors generally inhibits neurons, but its effect excitatory. Methods In vivo recording colorectal propulsion was used to investigate interaction between DRD2 GHSR1a. Localization studies were determine sites expression rat human Key Results Dopamine, agonist, quinpirole, directly applied cord, caused defecation. The intrathecal dopamine inhibited GHSR1a antagonist, YIL781, given systemically, YIL781 an antagonist DRD2. pramipexole, administered systemically that prevented when pelvic nerves cut. Drd2 Ghsr expressed together preganglionic level centers human. Behaviorally induced (caused water avoidance stress) reduced sulpiride. We had previously shown it YIL781. Conclusions Inferences Our observations imply a transmitter pathways whose are exerted through interacting (D2) on project colorectum. results explain excitation conservation absence ghrelin.