Combining modelling and experimental approaches to explain how calcium signatures are decoded by calmodulin‐binding transcription activators (CAMTAs) to produce specific gene expression responses

• DOI: 10.1111/nph.13428
• Publication Date: 2015-04-27T14:45:22Z
• Authors: Junli Liu; Helen J. Whalley; Marc R. Knight
• Keywords: 0301 basic medicine; 570; Ccalcium signatures; Mathematical modelling; Arabidopsis Proteins; Research; Calcium-Binding Proteins; Arabidopsis; Gene Expression; Genes, Plant; Models, Biological; Mathematical modelling.; 03 medical and health sciences; Calmodulin; Calmodulin-binding transcription activators (CAMTAs); Gene Expression Regulation, Plant; Multigene Family; Trans-Activators; Calcium; Gene expression; Calmodulin (CaM); Signal Transduction

Summary Experimental data show that Arabidopsis thaliana is able to decode different calcium signatures produce specific gene expression responses. It also known calmodulin‐binding transcription activators ( CAMTA s) have calmodulin (CaM)‐binding domains. Therefore, the responses regulated by s respond signals. However, little about how are decoded A dynamic model of Ca 2+ –CaM– binding and developed following thermodynamic kinetic principles. The parameterized using experimental data. Then it used analyse Modelling analysis reveals that: signals in form cytosolic concentration elevations nonlinearly amplified , CaM s; amplification enables be give ‐regulated responses; a signature depend upon its history accumulate all information during lifetime signature. Information flow from has been established combining with mathematical modelling.