Intraoral human herpes viruses detectable by PCR in majority of patients

• DOI: 10.1111/odi.13523
• Publication Date: 2020-07-01T16:52:52Z
• Authors: Tami Yap; Shuan Khor; Jung Seo Kim; Jaeyoung Kim; Jenny Sung Won Yun; Johannes S. Kern; Raymond Martyres; George Varigos; Hiu Tat Chan; Michael J. McCull...; Melissa L Thomas; Laura Scardamaglia
• Keywords: Multiplex

Abstract Objectives To identify factors which influence the intraoral prevalence of human herpes viruses (HHVs) using mucosal swabs, saliva samples and qPCR analysis. Methodology In this cross‐sectional observational study, matched oral swabs were collected from a total 115 subjects: 70 immunocompetent subjects with no abnormalities, 22 abnormalities 23 therapeutically immunocompromised individuals. Extracted DNA was analysed by multiplex for detection quantification HHVs 1–6. Results At least one virus detected in 77.1% individuals EBV most commonly at 61.4%. HHV‐6 17.1%, HSV‐1 4.3% CMV 1.1%. Detection higher than swabs. There HSV‐2 or VZV. Neither presence abnormality nor therapeutic immunocompromise related to increased virus. Conclusion Commensal rates are high, caution clinical correlation positive is warranted. low, likely be clinically relevant. This study presents comprehensive commensal rate 1–6