Immunohistochemical Evaluation of p300, H2AacK5 and H3AcK27 in Odontogenic Cysts and Tumors

• DOI: 10.1111/odi.15164
• Publication Date: 2024-10-22T09:46:37Z
• Authors: Luciane De Jesus ...; Douglas Magno Gui...; Alann Thaffarell ...; Karolyny Martins ...; Maria Sueli da Si...; Sérgio de Melo Al...; Fabio Daumas Nunes; Marcos José Custó...; João de Jesus Via...
• Keywords: Keratocyst; Odontogenic myxoma; Odontogenic tumor; Adenomatoid odontogenic tumor

ABSTRACT The acetylation of histones H2A on lysine 5 (H2AacK5) and H3 27 (H3AcK27) modulate several cellular mechanisms through the p300 enzyme in pathological lesions; however, their role odontogenic lesions has not been addressed. This study aims to evaluate immunoexpression p300, H2AacK5, H3AcK27 samples ameloblastoma (AMB) ( n = 30), keratocyst (OK) 15), adenomatoid tumor (AOT) 10), fibroma (OF) 8), calcifying cyst (COC) myxoma (MIX) ameloblastic (AF) 06). percentage p300‐positive cells was higher AOT decreased COC, OK, AMB, AF, OF, MIX. H2AacK5‐positive were AF AOT, MIX, whereas H3acK27‐positive expression these proteins nonaggressive comparison aggressive lesions. There a positive correlation between H3acK27 there H2AacK5 COC. histone may be involved biological behavior lesions, which could used improve diagnosis treatment.