EAACI Molecular Allergology User's Guide

• DOI: 10.1111/pai.12563
• Publication Date: 2016-06-11T15:25:15Z
• Authors: P. M. Matricardi; J. Kleine‐Tebbe; H. J. Hoffmann; R. Valenta; C. Hilger; S. Hofmaier; R. C. Aalberse; I. Agache; R. Asero; B. Ballmer‐Weber; D. Barber; K. Beyer; T. Biedermann; M. B. Bilò; S. Blank; B. Bohle; P. P. Bosshard; H. Breiteneder; H. A. Brough; L. Caraballo; J. C. Caubet; R. Crameri; J. M. Davies; N. Douladiris; M. Ebisawa; P. A. EIgenmann; M. Fernandez‐Rivas; F. Ferreira; G. Gadermaier; M. Glatz; R. G. Hamilton; T. Hawranek; P. Hellings; K. Hoffmann‐Somme...; T. Jakob; U. Jappe; M. Jutel; S. D. Kamath; E. F. Knol; P. Korosec; A. Kuehn; G. Lack; A. L. Lopata; M. Mäkelä; M. Morisset; V. Niederberger; A. H. Nowak‐Węgrzyn; N. G. Papadopoulos; E. A. Pastorello; G. Pauli; T. Platts‐Mills; D. Posa; L. K. Poulsen; M. Raulf; J. Sastre; E. Scala; J. M. Schmid; P. Schmid‐Grendel...; M. van Hage; R. van Ree; S. Vieths; R. Weber; M. Wickman; A. Muraro; M. Ollert
• Keywords: Basophil activation; Dander; Cross-reactivity

The availability of allergen molecules ('components') from several protein families has advanced our understanding immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). European Academy Allergy Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens describes the diagnostic options using CRD. Part A EAACI MAUG introduces molecules, families, composition extracts, databases, IgE, skin, basophil tests. Singleplex multiplex IgE assays with components improve both sensitivity for low-abundance analytical specificity; to individual can yield clinical risks distinguish cross-reactivity true primary sensitization. B discusses molecular aspects IgE-mediated allergies foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, shellfish), inhalants (pollen, mold spores, mites, animal dander), Hymenoptera venom. Diagnostic algorithms short case histories provide useful workup allergic individuals targeted C covers containing ubiquitous, highly cross-reactive panallergens plant (lipid transfer proteins, polcalcins, PR-10, profilins) sources (lipocalins, parvalbumins, serum albumins, tropomyosins) explains their utility. D lists 100 molecules. In conclusion, reactions diseases, including rhinoconjunctivitis, asthma, food reactions, insect sting are discussed a novel perspective. documents rapid progression allergology basic research its integration into practice, quantum leap in management patients.