Diet‐associated vertically transferred metabolites and risk of asthma, allergy, eczema, and infections in early childhood

• DOI: 10.1111/pai.13917
• Publication Date: 2023-02-17T15:49:48Z
• Authors: Nicklas Brustad; Alessandra Olarini; Min Kim; Liang Chen; Mina Ali; Tingting Wang; Arieh S. Cohen; Madeleine Ernst; David Hougaard; Ann‐Marie Schoos; Jakob Stokholm; Klaus Bønnelykke; Jessica Lasky‐Su; Morten A. Rasmussen; Bo Chawes
• Keywords: 2. Zero hunger; Eczema; 610; asthma; metabolomics; Infectious Disease Transmission, Vertical; Asthma; 3. Good health; Diet; COPSAC; 03 medical and health sciences; COPSAC; asthma; eczema; infections; metabolomics; 0302 clinical medicine; Pregnancy; Child, Preschool; Prenatal Exposure Delayed Effects; Hypersensitivity; Animals; Humans; Female; eczema; infections

Evidence suggests maternal pregnancy dietary intake and nutrition in the early postnatal period to be of importance for newborn child's health. However, studies investigating diet-related metabolites transferred from mother child on disease risk childhood are lacking. We sought investigate influence vertically atopic diseases infections during preschool age.In Danish population-based COPSAC2010 mother-child cohort, information 10 metabolomics profiles dried blood spots (DBS) at age 2-3 days was analyzed relation asthma, allergy, eczema, using principal component single metabolite analyses.In 678 children with DBS measurements, a coffee-related profile reflected by 1 inversely associated asthma (odds ratio (95% CI) 0.78 (0.64; 0.95), p = .014) eczema 6 years (0.79 (0.65; 0.97), .022). Furthermore, increasing stachydrine (fruit-related), 3-carboxy-4-methyl-5-propyl-2-furanpropanoate (fish-related), ergothioneine (fruit-, green vegetables-, fish-related) levels were all significantly reduced risks 0-3 (p < .05).This study demonstrates associations between measured life childhood. The specific may contribute characterization healthy nutritional metabolomics-based unbiased tool predicting